Gauteng police say the victim had just concluded with Friday prayers, and had made his way to his car when he was subsequently accosted by 2 unknown suspects, who shot at him several times. The suspects fled the scene in a silver VW Polo.
The 30-year-old victim was taken to hospital where he later died due to his injuries.
"The motive for the shooting is unknown at this stage and the police have launched a manhunt for the suspects," captain Mavela Masondo said in a statement on Friday.
He appealed to anyone with information to come forward that could help arrest the suspects.
There has been a spate of attacks on mosques in South Africa this year.
In November, a 30-year-old man was shot and killed, and an imam was injured in an attack on a Cape Town mosque.
In June, two men died after an attack at a Malmesbury mosque in Cape Town
Meanwhile, the state has provisionally withdrawn charges against seven of the 19 men arrested in connection with a mosque attack in Verulam, outside Durban, earlier this year.
The arrests followed the attack in May when unknown men stormed the Imam Hussain Mosque in Ottawa, Verulam, north of Durban, killing Abbas Essop.
During the attack, part of the Shia mosque was set alight and an explosive device was found in the building a few days later.
Source: News24.com